Core Facilities

A well defined and critical set of core facilities and shared services are needed to support the objectives of the SISCB/RM in the building. Some basic services are already available to faculty elsewhere on campus, and we will continue to leverage these important resources. However, the Lokey Stem Cell (SIM1) Building provides an opportunity to establish heretofore unavailable state-of-the-art shared services and to expand services that are critically limited in capacity for the stem cell research community. These cores are necessary to support both ongoing research and anticipated growth over the next 10 years. The Lokey Stem Cell cores will be available to researchers at Stanford and collaborating institutions, with priority given to the building occupants and CIRM-funded researchers. In this section, we provide a description of the cores that will be established, underscore the unique aspect or utility of each core and then describe the types of savings that can be achieved through shared services. Finally, we close with a description of some of the many other cores available elsewhere at Stanford University that are necessary to support the efforts of the SISCB/RM.

Core facilities, when appropriately designed and located have the potential to transform the scientific landscape of an Institution. Thus, we designed key cores for occupancy in the building, always keeping in mind that all stem cells are rare cells in tissues, cancers, and pluripotent culture-derived tissue stem cells, thus mandating the need for special services and equipment for stem cell research.

I. Shared Services in the Lokey Stem Cell Building

II. Cores Enable Significant Savings and Further Invigorate the Research

III. Administrative Programs

IV. Establishment, Operation and Management of Cores at Stanford

Stanford University has a long history of operating significant numbers of cores of remarkable complexity. In Section 6C, we provide details regarding the formal requirements needed to start and operate cores at Stanford, and the organizations that provide oversight for the cores.

Summary

The Cores of the building provide unique resources, unparalleled elsewhere, and are designed to augment those of the greater Stanford University community in order to enable stem cell research in the Elements X, Y and Z. The business model for the cores makes them affordable to investigators while providing services that would not otherwise be available.